The revolutionary new way of treating tooth decay was discovered by Professor Paul Sharpe of King’s College London Dental Institute. This way is based on teaching the body to regenerate damaged teeth in a short period of time, by Tideglusib.
Before starting to use this drug it is very important to understand how the body usually responds to damage or infection.
Because of the tooth trauma, the soft pulp on the inside of the tooth becomes exposed to the elements, which can cause an infection. When it happens the body responds by triggering the production of a very thin layer of dentine as a protectant. This thin protecting layer can’t withstand an injury or a major cavity, so the dentists use the filling in the missing tooth minerals with an artificial aggregate. The filling eliminates pain and prevents the spread of infection, but it yet doesn’t actually heal the damage done to the tooth.
According to the researchers, by treating a cavity with Tideglusib, actually is triggered the body to heal a cavity completely and are restored the lost minerals. The approach of the researchers is based on a dentine restoration that stimulates the natural formation of reparative dentine. This natural formation is stimulated via the mobilization of resident stem cells in the tooth pulp.
Tideglusib actually interferes with the enzyme that tells the body to produce that thin dentine layer to cover the damaged tooth. This signal is important for controlling the production of the dentine.
What are the results of testing Tideglusib in the lab?
The team of the researchers (Vitor C. M. Neves, Rebecca Babb, Dhivya Chandrasekaran & Paul T. Sharpe) experimented on the lab mice by applying collagen sponges soaked with Tideglusib to their damaged teeth. They experienced positive results and after 6 weeks the teeth were almost completely repaired.
Degraded sponges were replaced by naturally produced dentine and it resulted in a complete repair of the tooth. According to Sharpe, these promising results could be the start of a completely new approach to treating tooth decay.
There are not enough researches conducted, but Tideglusib has already been approved to test as a treatment for Alzheimer’s disease and the researchers are optimistic that this dental treatment could be relatively fast not only in the clinical trials but to the markets, too.